RNA Polymerase II: Difference between revisions
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3. <scene name='82/824648/Tfiif/1'>TFIIF</scene> binds directly to RNAP II and escorts it to the promoter while <scene name='82/824648/Tfiib/1'>TFIIB</scene> helps the complex bind correctly. | 3. <scene name='82/824648/Tfiif/1'>TFIIF</scene> binds directly to RNAP II and escorts it to the promoter while <scene name='82/824648/Tfiib/1'>TFIIB</scene> helps the complex bind correctly. | ||
4. <scene name='82/824648/Tfiie/1'>TFIIE</scene> and <scene name='82/824648/Tfiih/1'>TFIIH</scene> are sequentually recruited which completes the PIC. | 4. <scene name='82/824648/Tfiie/1'>TFIIE</scene> and <scene name='82/824648/Tfiih/1'>TFIIH</scene> are sequentually recruited which completes the <scene name='82/824648/Pic/1'>PIC</scene>. | ||
PIC NON-TRANSPARENT COMPLEX | PIC NON-TRANSPARENT COMPLEX | ||
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CENTERING F | CENTERING F | ||
Once the PIC is formed, RNAP II initiates RNA synthesis and produces a short transcript. When RNAP II becomes phosphorylated, it releases some of the GTFs from the complex and moves away from the promoter. TFIID stays bound to the promoter and can reinitiate transcription. The transcription factors are replaced by a new six-protein complex call the Elongator. TFIIF and TFIIH both remain associated with RNAP II during elongation. | Once the <scene name='82/824648/Pic/1'>PIC</scene> is formed, RNAP II initiates RNA synthesis and produces a short transcript. When RNAP II becomes phosphorylated, it releases some of the GTFs from the complex and moves away from the promoter. TFIID stays bound to the promoter and can reinitiate transcription. The transcription factors are replaced by a new six-protein complex call the Elongator. TFIIF and TFIIH both remain associated with RNAP II during elongation. | ||
