6nmy: Difference between revisions

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'''Unreleased structure'''


The entry 6nmy is ON HOLD until Paper Publication
==A Cytokine-receptor complex==
 
<StructureSection load='6nmy' size='340' side='right'caption='[[6nmy]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6nmy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NMY FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmy OCA], [http://pdbe.org/6nmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nmy RCSB], [http://www.ebi.ac.uk/pdbsum/6nmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmy ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[http://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. [[http://www.uniprot.org/uniprot/IL3RA_HUMAN IL3RA_HUMAN]] This is a receptor for interleukin-3. [[http://www.uniprot.org/uniprot/IL3_HUMAN IL3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Broughton, S E]]
[[Category: Dhagat, U]]
[[Category: Hercus, T R]]
[[Category: Kan, W L]]
[[Category: Lopez, A F]]
[[Category: Nero, T L]]
[[Category: Parker, M W]]
[[Category: Cell surface]]
[[Category: Cytokine]]
[[Category: Cytokine-receptor complex]]
[[Category: Receptor assembly]]
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