Sandbox GGC8: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<scene name='78/781194/87_-58_his/ | <scene name='78/781194/87_-58_his/8'>Proximal His87 and the distal His 58</scene>The α chain heme pocket with the relative orientation of the proximal Hisα87 and the distal Hisα58.proximal Hisα87(F8) is closer to the heme Fe atom by 0.10 Å more in the T-state compare to the R-state.<ref>doi: 10.1074/jbc.M109.066027</ref> | ||
<scene name='78/781194/92-63/5'>Proximal 92 His and distal 63 His</scene> The β chain heme pocket with the proximal Hisβ92(F8) and the distal Hisβ63(E7). In the R-state the proximal Hisβ92(F8) reorients itself to a more symmetric position relative to the heme molecule. In the T-state, the distal histidine E7 residue is positioned such that it partially blocks the oxygen-binding site. During the R → T transition, Hisβ63(E7) aligns itself with the heme Fe, and the Fe-His distances increase by a small but detectable amount<ref>doi: 10.1074/jbc.M109.066027</ref> | <scene name='78/781194/92-63/5'>Proximal 92 His and distal 63 His</scene> The β chain heme pocket with the proximal Hisβ92(F8) and the distal Hisβ63(E7). In the R-state the proximal Hisβ92(F8) reorients itself to a more symmetric position relative to the heme molecule. In the T-state, the distal histidine E7 residue is positioned such that it partially blocks the oxygen-binding site. During the R → T transition, Hisβ63(E7) aligns itself with the heme Fe, and the Fe-His distances increase by a small but detectable amount<ref>doi: 10.1074/jbc.M109.066027</ref> | ||
