Sandbox GGC14: Difference between revisions

Fibrinogen is an essential protein in the coagulation, which is initiated through either an instinctive or extinctive pathway. Both pathways trigger a cascade of reactions that lead to coagulation. At some point the protease thrombin is activated, thrombin then converts fibrinogen to fibrin. It does this by cleaving both the fibrinopeptide A and B off of the amino terminus of the alpha and beta chains. The alpha and beta knobs will bind to A and B holes of other fibrin molecules making a fibrin mesh strong enough to hold the platelet plug.