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ISSN 2310-6301 As life is more than 2D, Proteopedia helps to bridge the gap between 3D structure & function of biomacromolecules Proteopedia presents this information in a user-friendly way as a collaborative & free 3D-encyclopedia of proteins & other biomolecules.
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Coronavirus COVID-19 A novel coronavirus was found to be the cause of a respiratory illness first detected in Wuhan, China in 2019. 3D structural studies are aiding scientists to understand how the coronavirus infects humans and helping to find new ways to treat the viral spread (video by Fusion Animation). >>> Visit this page >>>	Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. IB Tomasic, MC Metcalf, AI Guce, NE Clark, SC Garman. J. Biol. Chem. 2010 doi: 10.1074/jbc.M110.118588 The human lysosomal enzymes α-galactosidase and α-N-acetylgalactosaminidase share 46% amino acid sequence identity and have similar folds. Using a rational protein engineering approach, we interconverted the enzymatic specificity of α-GAL and α-NAGAL. The engineered α-GAL retains the antigenicity but has acquired the enzymatic specificity of α-NAGAL. Conversely, the engineered α-NAGAL retains the antigenicity but has acquired the enzymatic specificity of the α-GAL enzyme. Comparison of the crystal structures of the designed enzyme to the wild-type enzymes shows that active sites superimpose well, indicating success of the rational design. The designed enzymes might be useful as non-immunogenic alternatives in enzyme replacement therapy for treatment of lysosomal storage disorders such as Fabry disease. >>> Visit this I3DC complement >>>	2025 Nobel Prize by Wayne Decatur The 2025 Nobel Prize in Chemistry was awarded for studies of metal-organic frameworks. Against expectations, the building blocks of metal-organic frameworks turned out to form networks with large cavities and the materials have a wide range of far-reaching practical applications. >>> Visit this page >>>
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Jaime Prilusky, Joel L. Sussman, Angel Herraez