176d: Difference between revisions

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[[Image:176d.~~jpg~~|left|200px]]

[[Image:176d.png|left|200px]]

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~~'''~~NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA~~'''~~

===NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA===

~~==Overview==~~

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~~Peptide nucleic acids~~ (~~PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner~~. ~~The structure of a PNA-ribonucleic acid (RNA~~) ~~complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that~~ is ~~an antiparallel, right-handed double helix with Watson-Crick base pairing similar to~~ the ~~"A" form structure of RNA duplexes~~. ~~The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure~~-~~based design of antisense agents.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7519361}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7519361 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].

==Reference==

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[[Category: Pna]]

[[Category: Rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 09~~:33:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:04 2008''

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-[[Image:176d.jpg|left|200px]]
+{{Seed}}
+[[Image:176d.png|left|200px]]
 <!--
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 {{STRUCTURE_176d|  PDB=176d  |  SCENE=  }}
-'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA'''
+===NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA===
-==Overview==
+<!--
-Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
+The line below this paragraph, {{ABSTRACT_PUBMED_7519361}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7519361 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7519361}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].
 ==Reference==
@@ Line 26: / Line 30: @@
 [[Category: Pna]]
 [[Category: Rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:33:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:04 2008''