177d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:177d.jpg|left|200px]]
{{Seed}}
[[Image:177d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_177d|  PDB=177d  |  SCENE=  }}  
{{STRUCTURE_177d|  PDB=177d  |  SCENE=  }}  


'''SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE'''
===SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE===




==Overview==
<!--  
The solution structure of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple has been determined via two and three-dimensional NMR spectroscopy and restrained molecular dynamics simulations incorporating explicit solvent and counter-ions. The T.CG triple, which expands the triplex code, is stabilized by a single hydrogen bond between the O-2 atom of thymine and the free amino proton of cytosine in the Watson-Crick C.G base-pair. This hydrogen bonding alignment produces large variations in helical twist at the dinucleotide steps involving the thymine residue. Localized structural perturbations in the purine-rich strand of the molecule are observed around the cytosine residue in the T.CG triple. Globally, the triplex resembles the solution structure of a previously solved pyrimidine.purine.pyrimidine DNA triplex containing an unusual G.TA triple. Also conserved are the sites and patterns of hydration in the two triplexes.
The line below this paragraph, {{ABSTRACT_PUBMED_8057381}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8057381 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8057381}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=177D OCA].  


==Reference==
==Reference==
Line 25: Line 29:
[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Triplex]]
[[Category: Triplex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:33:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:32 2008''

Revision as of 12:36, 30 June 2008

File:177d.png

Template:STRUCTURE 177d

SOLUTION STRUCTURE AND HYDRATION PATTERNS OF A PYRIMIDINE(DOT)PURINE(DOT)PYRIMIDINE DNA TRIPLEX CONTAINING A NOVEL T(DOT)CG TRIPLE

Template:ABSTRACT PUBMED 8057381

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure and hydration patterns of a pyrimidine.purine.pyrimidine DNA triplex containing a novel T.CG base-triple., Radhakrishnan I, Patel DJ, J Mol Biol. 1994 Aug 26;241(4):600-19. PMID:8057381

Page seeded by OCA on Mon Jun 30 15:36:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=177d&oldid=570060"