198d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:198d.gif|left|200px]]
{{Seed}}
[[Image:198d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_198d|  PDB=198d  |  SCENE=  }}  
{{STRUCTURE_198d|  PDB=198d  |  SCENE=  }}  


'''A TRIGONAL FORM OF THE IDARUBICIN-D(CGATCG) COMPLEX: CRYSTAL AND MOLECULAR STRUCTURE AT 2.0 ANGSTROMS RESOLUTION'''
===A TRIGONAL FORM OF THE IDARUBICIN-D(CGATCG) COMPLEX: CRYSTAL AND MOLECULAR STRUCTURE AT 2.0 ANGSTROMS RESOLUTION===




==Overview==
<!--
The X-ray crystal structure of the complex between the anthracycline idarubicin and d(CGATCG) has been solved by molecular replacement and refined to a resolution of 2.0 A. The final R-factor is 0.19 for 3768 reflections with Fo &gt; or = 2 sigma (Fo). The complex crystallizes in the trigonal space group P31 with unit cell parameters a = b = 52.996(4), c = 33.065(2) A, alpha = beta = 90 degree, gamma = 120 degree. The asymmetric unit consists of two duplexes, each one being complexed with two idarubicin drugs intercalated at the CpG steps, one spermine and 160 water molecules. The molecular packing underlines major groove-major groove interactions between neighbouring helices, and an unusually low value of the occupied fraction of the unit cell due to a large solvent channel of approximately 30 A diameter. This is the first trigonal crystal form of a DNA-anthracycline complex. The structure is compared with the previously reported structure of the same complex crystallizing in a tetragonal form. The geometry of both the double helices and the intercalation site are conserved as are the intramolecular interactions despite the different crystal forms.
The line below this paragraph, {{ABSTRACT_PUBMED_7784175}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7784175 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_7784175}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Right handed dna]]
[[Category: Right handed dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:35:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:41:01 2008''

Revision as of 12:41, 30 June 2008

File:198d.png

Template:STRUCTURE 198d

A TRIGONAL FORM OF THE IDARUBICIN-D(CGATCG) COMPLEX: CRYSTAL AND MOLECULAR STRUCTURE AT 2.0 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 7784175

About this Structure

Full crystallographic information is available from OCA.

Reference

A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 A resolution., Dautant A, Langlois d'Estaintot B, Gallois B, Brown T, Hunter WN, Nucleic Acids Res. 1995 May 25;23(10):1710-6. PMID:7784175

Page seeded by OCA on Mon Jun 30 15:41:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=198d&oldid=570241"