Sandbox Reserved 1563: Difference between revisions
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== '''Function(s) and Biological Relevance''' == | == '''Function(s) and Biological Relevance''' == | ||
Inosine-5'-monophosphate dehydrogenase (IMPDH) catalyzes the rate limiting step of the de novo guanine nucleotide biosynthetic pathway. NAD is reduced resulting in IMP converting to Xanthosine monophosphate (XMP). | Inosine-5'-monophosphate dehydrogenase (IMPDH) catalyzes the rate limiting step of the de novo guanine nucleotide biosynthetic pathway. NAD is reduced resulting in IMP converting to Xanthosine monophosphate (XMP). IMPDH is found in organisms that go through the purine biosynthetic pathway, this includes humans. | ||
== '''Broader Implications''' == | == '''Broader Implications''' == | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
1. Fernández-Justel, D.; Peláez, R.; Revuelta, J. L.; Buey, R. M. The Bateman Domain of IMP Dehydrogenase Is a Binding Target for Dinucleoside Polyphosphates. J Biol Chem 2019, 294 (40), 14768–14775. | |||
