Neurotransmitters: Difference between revisions
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* [[Journal:JBSD:2|Neurotensin]] | * [[Journal:JBSD:2|Neurotensin]] | ||
==Neurotensin receptors== | ==Neurotensin receptors== | ||
he neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs). Currently around 800 G protein-coupled receptors have been identified and are hypothesized to be responsible for roughly 80% of [https://en.wikipedia.org/wiki/Signal_transduction signal transduction].<ref name="Millar">PMID:20019124</ref> GPCRs are involved in a vast array of physiological processes within the body that range from interactions with [https://en.wikipedia.org/wiki/Dopamine dopamine] to effects on secretion of bile in the intestines.<ref name="Gui">PMID:11208724</ref> <ref name="Binder">PMID:1173461</ref> Due to the vast array of functions that these proteins serve and their high abundance within the body, these proteins have become major drug targets.<ref name="Fang">PMID:23573662</ref> | |||
The ligand for NTSR1 is the 13 amino acid peptide, neurotensin (NTS)<ref name="SONT">PMID:23051748</ref>, and the majority of the effects of NTS are mediated through NTSR1<ref name="SONT"/>. NTS has a variety of biological activities including a role in the '''[https://en.wikipedia.org/wiki/Leptin leptin]''' signaling pathways <ref name="Mice">PMID: 20211191</ref>, tumor growth <ref name="cancer">PMID:16887236</ref>, and '''[https://en.wikipedia.org/wiki/Dopamine dopamine]''' regulation <ref name="Schizophrenia">PMID:22596253</ref>. NTSR1 was crystallized bound with a C-terminal portion of its tridecapeptide '''[https://en.wikipedia.org/wiki/Ligand ligand]''', <scene name='72/721548/Neurotensin/7'>NTS(8-13)</scene>. The shortened ligand was used because of oits higher potency and efficacy than its full-length counterpart<ref name="SONT"/>. | |||
[[Neurotensin receptor]] | [[Neurotensin receptor]] | ||
