6v2r: Difference between revisions

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'''Unreleased structure'''


The entry 6v2r is ON HOLD
==Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866==
 
<StructureSection load='6v2r' size='340' side='right'caption='[[6v2r]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6v2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V2R FirstGlance]. <br>
Description: Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5R0:4-~{TERT}-BUTYLBENZOIC+ACID'>5R0</scene>, <scene name='pdbligand=5R5:METHYL+(2~{S})-2-AZANYL-3-OXIDANYL-PROPANOATE'>5R5</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene></td></tr>
[[Category: Frye, S.V]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v2r OCA], [http://pdbe.org/6v2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v2r RCSB], [http://www.ebi.ac.uk/pdbsum/6v2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v2r ProSAT]</span></td></tr>
[[Category: Dickson, B.M]]
</table>
[[Category: James, L.I]]
== Function ==
[[http://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Dickson, B M]]
[[Category: Edwards, A M]]
[[Category: Frye, S V]]
[[Category: James, L I]]
[[Category: Liu, Y]]
[[Category: Min, J]]
[[Category: Min, J]]
[[Category: Edwards, A.M]]
[[Category: Structural genomic]]
[[Category: Arrowsmith, C.H]]
[[Category: Stuckey, J I]]
[[Category: Walker, J.R]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Liu, Y]]
[[Category: Stuckey, J.I]]
[[Category: Bountra, C]]
[[Category: Tempel, W]]
[[Category: Tempel, W]]
[[Category: Walker, J R]]
[[Category: Gene regulation]]
[[Category: Sgc]]
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