1a0p: Difference between revisions

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[[Image:1a0p.jpg|left|200px]]
{{Seed}}
[[Image:1a0p.png|left|200px]]


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{{STRUCTURE_1a0p|  PDB=1a0p  |  SCENE=  }}  
{{STRUCTURE_1a0p|  PDB=1a0p  |  SCENE=  }}  


'''SITE-SPECIFIC RECOMBINASE, XERD'''
===SITE-SPECIFIC RECOMBINASE, XERD===




==Overview==
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The structure of the site-specific recombinase, XerD, that functions in circular chromosome separation, has been solved at 2.5 A resolution and reveals that the protein comprises two domains. The C-terminal domain contains two conserved sequence motifs that are located in similar positions in the structures of XerD, lambda and HP1 integrases. However, the extreme C-terminal regions of the three proteins, containing the active site tyrosine, are very different. In XerD, the arrangement of active site residues supports a cis cleavage mechanism. Biochemical evidence for DNA bending is encompassed in a model that accommodates extensive biochemical and genetic data, and in which the DNA is wrapped around an alpha-helix in a manner similar to that observed for CAP complexed with DNA.
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{{ABSTRACT_PUBMED_9311978}}


==About this Structure==
==About this Structure==
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[[Category: Recombinase]]
[[Category: Recombinase]]
[[Category: Xerd]]
[[Category: Xerd]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:38:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:44:48 2008''

Revision as of 12:44, 30 June 2008

File:1a0p.png

Template:STRUCTURE 1a0p

SITE-SPECIFIC RECOMBINASE, XERD

Template:ABSTRACT PUBMED 9311978

About this Structure

1A0P is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the site-specific recombinase, XerD., Subramanya HS, Arciszewska LK, Baker RA, Bird LE, Sherratt DJ, Wigley DB, EMBO J. 1997 Sep 1;16(17):5178-87. PMID:9311978

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