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| {{STRUCTURE_1a12| PDB=1a12 | SCENE= }} | | {{STRUCTURE_1a12| PDB=1a12 | SCENE= }} |
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| '''REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN'''
| | ===REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN=== |
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| ==Overview==
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| The gene encoding the regulator of chromosome condensation (RCC1) was cloned by virtue of its ability to complement the temperature-sensitive phenotype of the hamster cell line tsBN2, which undergoes premature chromosome condensation or arrest in the G1 phase of the cell cycle at non-permissive temperatures. RCC1 homologues have been identified in many eukaryotes, including budding and fission yeast. Mutations in the gene affect pre-messenger RNA processing and transport, mating, initiation of mitosis and chromatin decondensation, suggesting that RCC1 is important in the control of nucleo-cytoplasmic transport and the cell cycle. Biochemically, RCC1 is a guanine-nucleotide-exchange factor for the nuclear Ras homologue Ran; it increases the dissociation of Ran-bound GDP by 10(5)-fold. It may also bind to DNAvia a protein-protein complex. Here we show that the structure of human RCC1, solved to 1.7-A resolution by X-ray crystallography, consists of a seven-bladed propeller formed from internal repeats of 51-68 residues per blade. The sequence and structure of the repeats differ from those of WD40-domain proteins, which also form seven-bladed propellers and include the beta-subunits of G proteins. The nature of the structure explains the consequences of a wide range of known mutations. The region of the protein that is involved in guanine-nucleotide exchange is located opposite the region that is thought to be involved in chromosome binding. | | The line below this paragraph, {{ABSTRACT_PUBMED_9510255}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9510255 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9510255}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ran]] | | [[Category: Ran]] |
| [[Category: Ras-like nuclear gtp binding protein]] | | [[Category: Ras-like nuclear gtp binding protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:38:55 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:45:42 2008'' |
