1a15: Difference between revisions

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[[Image:1a15.gif|left|200px]]
{{Seed}}
[[Image:1a15.png|left|200px]]


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{{STRUCTURE_1a15|  PDB=1a15  |  SCENE=  }}  
{{STRUCTURE_1a15|  PDB=1a15  |  SCENE=  }}  


'''SDF-1ALPHA'''
===SDF-1ALPHA===




==Overview==
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Stromal cell-derived factor-1alpha (SDF-1alpha ) is a member of the chemokine superfamily and functions as a growth factor and chemoattractant through activation of CXCR4/LESTR/Fusin, a G protein-coupled receptor. This receptor also functions as a coreceptor for T-tropic syncytium-inducing strains of HIV-1. SDF-1alpha antagonizes infectivity of these strains by competing with gp120 for binding to the receptor. The crystal structure of a variant SDF-1alpha ([N33A]SDF-1alpha ) prepared by total chemical synthesis has been refined to 2.2-A resolution. Although SDF-1alpha adopts a typical chemokine beta-beta-beta-alpha topology, the packing of the alpha-helix against the beta-sheet is strikingly different. Comparison of SDF-1alpha with other chemokine structures confirms the hypothesis that SDF-1alpha may be either an ancestral protein from which all other chemokines evolved or the chemokine that is the least divergent from a primordial chemokine. The structure of SDF-1alpha reveals a positively charged surface ideal for binding to the negatively charged extracellular loops of the CXCR4 HIV-1 coreceptor. This ionic complementarity is likely to promote the interaction of the mobile N-terminal segment of SDF-1alpha with interhelical sites of the receptor, resulting in a biological response.
The line below this paragraph, {{ABSTRACT_PUBMED_9618518}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9618518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9618518}}


==About this Structure==
==About this Structure==
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[[Category: Chemokine]]
[[Category: Chemokine]]
[[Category: Human stromal cell-derived factor-1alpha]]
[[Category: Human stromal cell-derived factor-1alpha]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:39:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:45:53 2008''

Revision as of 12:45, 30 June 2008

File:1a15.png

Template:STRUCTURE 1a15

SDF-1ALPHA

Template:ABSTRACT PUBMED 9618518

About this Structure

1A15 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor., Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E, Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6941-6. PMID:9618518

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