1a1v: Difference between revisions

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[[Image:1a1v.gif|left|200px]]
{{Seed}}
[[Image:1a1v.png|left|200px]]


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{{STRUCTURE_1a1v|  PDB=1a1v  |  SCENE=  }}  
{{STRUCTURE_1a1v|  PDB=1a1v  |  SCENE=  }}  


'''HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA'''
===HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA===




==Overview==
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BACKGROUND: Hepatitis C virus (HCV) represents a major health concern as it is responsible for a significant number of hepatitis cases worldwide. Much research has focused on the replicative enzymes of HCV as possible targets for more effective therapeutic agents. HCV NS3 helicase may provide one such suitable target. Helicases are enzymes which can unwind double-stranded regions of DNA or RNA in an ATP-dependent reaction. The structures of several helicases have been published but the structural details as to how ATP binding and hydrolysis are coupled to RNA unwinding are unknown. RESULTS: The structure of the HCV NS3 RNA helicase domain complexed with a single-stranded DNA oligonucleotide has been solved to 2.2 A resolution. The protein consists of three structural domains with the oligonucleotide lying in a groove between the first two domains and the third. The first two domains have an adenylate kinase like fold, including a phosphate-binding loop in the first domain. CONCLUSIONS: HCV NS3 helicase is a member of a superfamily of helicases, termed superfamily II. Residues of NS3 helicase which are conserved among superfamily II helicases line an interdomain cleft between the first two domains. The oligonucleotide binds in an orthogonal binding site and contacts relatively few conserved residues. There are no strong sequence-specific interactions with the oligonucleotide bases.
The line below this paragraph, {{ABSTRACT_PUBMED_9493270}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9493270 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9493270}}


==About this Structure==
==About this Structure==
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[[Category: Rna helicase]]
[[Category: Rna helicase]]
[[Category: Single-stranded dna]]
[[Category: Single-stranded dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:41:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:49:06 2008''

Revision as of 12:49, 30 June 2008

File:1a1v.png

Template:STRUCTURE 1a1v

HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA

Template:ABSTRACT PUBMED 9493270

About this Structure

1A1V is a Single protein structure of sequence from Hepatitis c virus genotype 1a (isolate h). Full crystallographic information is available from OCA.

Reference

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding., Kim JL, Morgenstern KA, Griffith JP, Dwyer MD, Thomson JA, Murcko MA, Lin C, Caron PR, Structure. 1998 Jan 15;6(1):89-100. PMID:9493270

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