1a1w: Difference between revisions

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[[Image:1a1w.jpg|left|200px]]
{{Seed}}
[[Image:1a1w.png|left|200px]]


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{{STRUCTURE_1a1w|  PDB=1a1w  |  SCENE=  }}  
{{STRUCTURE_1a1w|  PDB=1a1w  |  SCENE=  }}  


'''FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE'''
===FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE===




==Overview==
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When activated, membrane-bound receptors for Fas and tumour-necrosis factor initiate programmed cell death by recruiting the death domain of the adaptor protein FADD to the membrane. FADD then activates caspase 8 (also known as FLICE or MACH) through an interaction between the death-effector domains of FADD and caspase 8. This ultimately leads to the apoptotic response. Death-effector domains and homologous protein modules known as caspase-recruitment domains have been found in several proteins and are important regulators of caspase (FLICE) activity and of apoptosis. Here we describe the solution structure of a soluble, biologically active mutant of the FADD death-effector domain. The structure consists of six antiparallel, amphipathic alpha-helices and resembles the overall fold of the death domains of Fas and p75. Despite this structural similarity, mutations that inhibit protein-protein interactions involving the Fas death domain have no effect when introduced into the FADD death-effector domain. Instead, a hydrophobic region of the FADD death-effector domain that is not present in the death domains is vital for binding to FLICE and for apoptotic activity.
The line below this paragraph, {{ABSTRACT_PUBMED_9582077}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9582077 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9582077}}


==About this Structure==
==About this Structure==
1A1W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1W OCA].  
1A1W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1W OCA].  


==Reference==
==Reference==
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[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Death effector domain]]
[[Category: Death effector domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:41:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:49:08 2008''

Revision as of 12:49, 30 June 2008

File:1a1w.png

Template:STRUCTURE 1a1w

FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9582077

About this Structure

1A1W is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain., Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, Lenardo MJ, Fesik SW, Nature. 1998 Apr 30;392(6679):941-5. PMID:9582077

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