Sandbox Reserved 1095

This Sandbox is Reserved from 25/11/2019, through 30/9/2020 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1091 through Sandbox Reserved 1115.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution.

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D History Searchers suspected since 70s the existence of diffrents angiotensin receptors. But it was only at the end of 80s that searchers had tools to identify these two distincts transmembrane receptors (AT1R and AT2R). Three labs discoveredin the same time these two receptors so they were some confusion about the nomenclature. So In 1991 a group of searchers met to make the nomenclature coherent. Finally, around 2015, researchers the crystal structure of the receptor in complex with its antagonist ZD7155 and with an inverse agonist olmesartan . They used x-ray cryogenic-crystallography. They found similar conformation of the receptor when it is link to the antagonist or to the inverse agonist. They also found conserved molecular recognition modes. So to complet the discovery, they realized some experiment with mutants to identify the différents residus which interact with the ligand. Application in the therapeutic field This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.