Sandbox Reserved 1563: Difference between revisions
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<scene name='82/823087/Impdh_triad/6'>IMPDH triad</scene>. The IMPDH triad includes Arg (320), Asn (306), and Asp (272). This is represented by the solid black structures in the image. This triad is important as it makes cystine more reactive, which in turn induces binding. | <scene name='82/823087/Impdh_triad/6'>IMPDH triad</scene>. The IMPDH triad includes Arg (320), Asn (306), and Asp (272). This is represented by the solid black structures in the image. This triad is important as it makes cystine more reactive, which in turn induces binding. | ||
<scene name='82/823087/Impdh_triad_active_binding/ | <scene name='82/823087/Impdh_triad_active_binding/5'>IMPDH active binding site</scene>. The active binding cite is where the binding takes place after the catalytic triad makes cystine more reactive and binding is induced. In the image the cystines are in white. This is where binding would occur. | ||
<scene name='82/823087/Impdh_charge/2'>IMPDH charge</scene>. IMPDH has no significant charge since it is found in physiological environments. Positively and negatively charged amino acids play a part in intermediate covalent binding steps<ref>PMID: 31416831</ref>. | <scene name='82/823087/Impdh_charge/2'>IMPDH charge</scene>. IMPDH has no significant charge since it is found in physiological environments. Positively and negatively charged amino acids play a part in intermediate covalent binding steps<ref>PMID: 31416831</ref>. | ||