6l1w: Difference between revisions
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==Zinc-finger Antiviral Protein (ZAP) bound to RNA== | |||
<StructureSection load='6l1w' size='340' side='right'caption='[[6l1w]], [[Resolution|resolution]] 2.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6l1w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L1W FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l1w OCA], [http://pdbe.org/6l1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l1w RCSB], [http://www.ebi.ac.uk/pdbsum/6l1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l1w ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ZCCHV_MOUSE ZCCHV_MOUSE]] Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).<ref>PMID:21102435</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Gao, G]] | |||
[[Category: Gao, P]] | |||
[[Category: Gao, Y]] | |||
[[Category: Liu, S]] | |||
[[Category: Luo, X]] | |||
[[Category: Wang, X]] | |||
[[Category: Zhu, J]] | |||
[[Category: Rna binding protein-rna complex]] | |||
Revision as of 08:18, 1 January 2020
Zinc-finger Antiviral Protein (ZAP) bound to RNA
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