5doc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 3: Line 3:
<StructureSection load='5doc' size='340' side='right'caption='[[5doc]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
<StructureSection load='5doc' size='340' side='right'caption='[[5doc]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5doc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcmva Hcmva]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5doc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DOC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dob|5dob]], [[5doe|5doe]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UL53 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10360 HCMVA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5doc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doc OCA], [https://pdbe.org/5doc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5doc RCSB], [https://www.ebi.ac.uk/pdbsum/5doc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5doc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5doc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5doc OCA], [http://pdbe.org/5doc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5doc RCSB], [http://www.ebi.ac.uk/pdbsum/5doc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5doc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UL53_HCMVA UL53_HCMVA]] Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, UL53/UL50 complex induces capsids budding and envelopment into the perinuclear space. Then UL53/UL50 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network (By similarity).  
[https://www.uniprot.org/uniprot/NEC1_HCMVA NEC1_HCMVA] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04023]<ref>PMID:25339763</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hcmva]]
[[Category: Human herpesvirus 5 strain AD169]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Filman, D J]]
[[Category: El Omari K]]
[[Category: Hogle, J M]]
[[Category: Filman DJ]]
[[Category: Lye, M F]]
[[Category: Hogle JM]]
[[Category: Omari, K El]]
[[Category: Lye MF]]
[[Category: Bergerat fold]]
[[Category: Conserved region]]
[[Category: Dna binding protein]]
[[Category: Zinc finger]]
Retrieved from "https://proteopedia.org/5doc"