5t1a: Difference between revisions

<table><tr><td colspan='2'>[[5t1a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T1A FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.806&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73R:(3S)-1-{(1S,2R,4R)-4-[METHYL(PROPAN-2-YL)AMINO]-2-PROPYLCYCLOHEXYL}-3-{[6-(TRIFLUOROMETHYL)QUINAZOLIN-4-YL]AMINO}PYRROLIDIN-2-ONE'>73R</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VT5:(2~{R})-1-(4-CHLORANYL-2-FLUORANYL-PHENYL)-2-CYCLOHEXYL-3-ETHANOYL-4-OXIDANYL-2~{H}-PYRROL-5-ONE'>VT5</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t1a OCA], [https://pdbe.org/5t1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t1a RCSB], [https://www.ebi.ac.uk/pdbsum/5t1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t1a ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/CCR2_HUMAN CCR2_HUMAN] Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.<ref>PMID:23408426</ref>  

[[Category: Escherichia virus T4]]

[[Category: Homo sapiens]]

[[Category: Abagyan R]]

[[Category: Carter P]]

[[Category: Cherezov V]]

[[Category: Cherney RJ]]

[[Category: Dabros M]]

[[Category: Gustavsson M]]

[[Category: Han GW]]

[[Category: Handel TM]]

[[Category: Heitman LH]]

[[Category: IJzerman AP]]

[[Category: Kufareva I]]

[[Category: Ortiz Zacarias NV]]

[[Category: Qin L]]

[[Category: Stamos D]]

[[Category: Stevens RC]]

[[Category: Tebben A]]

[[Category: Zhao C]]

[[Category: Zheng Y]]

[[Category: De Vries H]]