5t7q: Difference between revisions

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==TIRAP phosphoinositide-binding motif==
==TIRAP phosphoinositide-binding motif==
<StructureSection load='5t7q' size='340' side='right'caption='[[5t7q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5t7q' size='340' side='right'caption='[[5t7q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5t7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T7Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[5t7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T7Q FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7q OCA], [https://pdbe.org/5t7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t7q RCSB], [https://www.ebi.ac.uk/pdbsum/5t7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7q OCA], [http://pdbe.org/5t7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t7q RCSB], [http://www.ebi.ac.uk/pdbsum/5t7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5t7q" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5t7q" style="background-color:#fffaf0;"></div>
==See Also==
*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Armstrong, G]]
[[Category: Armstrong G]]
[[Category: Capelluto, D G.S]]
[[Category: Capelluto DGS]]
[[Category: Ellena, J F]]
[[Category: Ellena JF]]
[[Category: Xiao, S]]
[[Category: Xiao S]]
[[Category: Zhao, X]]
[[Category: Zhao X]]
[[Category: Phosphoinositide]]
[[Category: Phosphoinositide-binding motif]]
[[Category: Phosphorylation]]
[[Category: Signaling protein]]
[[Category: Structure]]
[[Category: Tirap]]
Retrieved from "https://proteopedia.org/5t7q"