5try: Difference between revisions

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<StructureSection load='5try' size='340' side='right'caption='[[5try]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5try' size='340' side='right'caption='[[5try]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRY FirstGlance]. <br>
<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TRY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7J0:(2~{S})-~{N}-[(2~{S})-3-METHOXY-1-(NAPHTHALEN-1-YLMETHYLAMINO)-1-OXIDANYLIDENE-PROPAN-2-YL]-4-OXIDANYLIDENE-2-(3-PHENYLPROPANOYLAMINO)-4-PIPERIDIN-1-YL-BUTANAMIDE'>7J0</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.000008&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5trg|5trg]], [[5trr|5trr]], [[5trs|5trs]], [[5ts0|5ts0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7J0:(2~{S})-~{N}-[(2~{S})-3-METHOXY-1-(NAPHTHALEN-1-YLMETHYLAMINO)-1-OXIDANYLIDENE-PROPAN-2-YL]-4-OXIDANYLIDENE-2-(3-PHENYLPROPANOYLAMINO)-4-PIPERIDIN-1-YL-BUTANAMIDE'>7J0</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prcA, MRA_2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), prcB, MRA_2125 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5try OCA], [https://pdbe.org/5try PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5try RCSB], [https://www.ebi.ac.uk/pdbsum/5try PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5try ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5try OCA], [http://pdbe.org/5try PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5try RCSB], [http://www.ebi.ac.uk/pdbsum/5try PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5try ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/PSB_MYCTA PSB_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.  
[https://www.uniprot.org/uniprot/PSA_MYCTU PSA_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Proteasome endopeptidase complex]]
[[Category: Fan, H]]
[[Category: Hsu, H C]]
[[Category: Li, H]]
[[Category: Lin, G]]
[[Category: Nathan, C]]
[[Category: Singh, P K]]
[[Category: Sukenick, G]]
[[Category: Wang, R]]
[[Category: C-capped dipeptide]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Proteasome]]
[[Category: Fan H]]
[[Category: Hsu H-C]]
[[Category: Li H]]
[[Category: Lin G]]
[[Category: Nathan C]]
[[Category: Singh PK]]
[[Category: Sukenick G]]
[[Category: Wang R]]
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