1a3k: Difference between revisions

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[[Image:1a3k.~~gif~~|left|200px]]

[[Image:1a3k.png|left|200px]]

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~~'''~~X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION~~'''~~

===X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION===

~~==Overview==~~

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~~Galectins are a family of lectins which share similar carbohydrate recognition domains (CRDs) and affinity for small beta-galactosides~~, ~~but which show significant differences in binding specificity for more complex glycoconjugates. We report here~~ the ~~x-ray crystal structure of~~ the ~~human galectin-3 CRD, in complex with lactose and N-acetyllactosamine,~~ at 2.~~1-A resolution~~. ~~This structure represents the first example of a CRD determined from a galectin which does not show~~ the ~~canonical 2-fold symmetric dimer organization~~. ~~Comparison with the published structures of galectins~~-~~1 and~~ -~~2 provides an explanation for the differences in carbohydrate-binding specificity shown by galectin-3, and for the fact that it fails to form dimers by analogous CRD-CRD interactions.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9582341}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9582341 is the PubMed ID number.

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==About this Structure==

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[[Category: Ige-binding protein]]

[[Category: Lectin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 09~~:45:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:56:06 2008''

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-[[Image:1a3k.gif|left|200px]]
+{{Seed}}
+[[Image:1a3k.png|left|200px]]
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 {{STRUCTURE_1a3k|  PDB=1a3k  |  SCENE=  }}
-'''X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION'''
+===X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION===
-==Overview==
+<!--
-Galectins are a family of lectins which share similar carbohydrate recognition domains (CRDs) and affinity for small beta-galactosides, but which show significant differences in binding specificity for more complex glycoconjugates. We report here the x-ray crystal structure of the human galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A resolution. This structure represents the first example of a CRD determined from a galectin which does not show the canonical 2-fold symmetric dimer organization. Comparison with the published structures of galectins-1 and -2 provides an explanation for the differences in carbohydrate-binding specificity shown by galectin-3, and for the fact that it fails to form dimers by analogous CRD-CRD interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_9582341}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9582341 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9582341}}
 ==About this Structure==
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 [[Category: Ige-binding protein]]
 [[Category: Lectin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:45:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:56:06 2008''