1a3q: Difference between revisions

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[[Image:1a3q.gif|left|200px]]
{{Seed}}
[[Image:1a3q.png|left|200px]]


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{{STRUCTURE_1a3q|  PDB=1a3q  |  SCENE=  }}  
{{STRUCTURE_1a3q|  PDB=1a3q  |  SCENE=  }}  


'''HUMAN NF-KAPPA-B P52 BOUND TO DNA'''
===HUMAN NF-KAPPA-B P52 BOUND TO DNA===




==Overview==
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The crystal structure of human NF-kappaB p52 in its specific complex with the natural kappaB DNA binding site MHC H-2 has been solved at 2.1 A resolution. Whereas the overall structure resembles that of the NF-kappaB p50-DNA complex, pronounced differences are observed within the 'insert region'. This sequence segment differs in length between different Rel proteins. Compared with NF-kappaB p50, the compact alpha-helical insert region element is rotated away from the core of the N-terminal domain, opening up a mainly polar cleft. The insert region presents potential interaction surfaces to other proteins. The high resolution of the structure reveals many water molecules which mediate interactions in the protein-DNA interface. Additional complexity in Rel protein-DNA interaction comes from an extended interfacial water cavity that connects residues at the edge of the dimer interface to the central DNA bases. The observed water network might acount for differences in binding specificity between NF-kappaB p52 and NF-kappaB p50 homodimers.
The line below this paragraph, {{ABSTRACT_PUBMED_9384586}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9384586 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9384586}}


==About this Structure==
==About this Structure==
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[[Category: Immune response]]
[[Category: Immune response]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:46:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:56:51 2008''

Revision as of 12:56, 30 June 2008

File:1a3q.png

Template:STRUCTURE 1a3q

HUMAN NF-KAPPA-B P52 BOUND TO DNA

Template:ABSTRACT PUBMED 9384586

About this Structure

1A3Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution., Cramer P, Larson CJ, Verdine GL, Muller CW, EMBO J. 1997 Dec 1;16(23):7078-90. PMID:9384586

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