1a41: Difference between revisions

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[[Image:1a41.gif|left|200px]]
{{Seed}}
[[Image:1a41.png|left|200px]]


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{{STRUCTURE_1a41|  PDB=1a41  |  SCENE=  }}  
{{STRUCTURE_1a41|  PDB=1a41  |  SCENE=  }}  


'''TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS'''
===TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS===




==Overview==
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Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA-(3'-phosphotyrosyl)-enzyme intermediate. A C-terminal catalytic domain, Topo(81-314), suffices for transesterification chemistry. The domain contains a constellation of five amino acids, conserved in all eukaryotic type IB topoisomerases, that catalyzes attack of the tyrosine nucleophile on the scissile phosphate. The structure of the catalytic domain, consisting of ten alpha helices and a three-strand beta sheet, resembles the catalytic domains of site-specific recombinases that act via a topoisomerase IB-like mechanism. The topoisomerase catalytic pentad is conserved in the tertiary structures of the recombinases despite scant sequence similarity overall. This implies that the catalytic domains of type IB topoisomerases and recombinases derive from a common ancestral strand transferase.
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{{ABSTRACT_PUBMED_9529259}}


==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Type 1b topoisomerase]]
[[Category: Type 1b topoisomerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:46:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:59:15 2008''

Revision as of 12:59, 30 June 2008

File:1a41.png

Template:STRUCTURE 1a41

TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS

Template:ABSTRACT PUBMED 9529259

About this Structure

1A41 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases., Cheng C, Kussie P, Pavletich N, Shuman S, Cell. 1998 Mar 20;92(6):841-50. PMID:9529259

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