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| [[Image:1a4k.gif|left|200px]] | | {{Seed}} |
| | [[Image:1a4k.png|left|200px]] |
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| {{STRUCTURE_1a4k| PDB=1a4k | SCENE= }} | | {{STRUCTURE_1a4k| PDB=1a4k | SCENE= }} |
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| '''DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE'''
| | ===DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE=== |
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| ==Overview==
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| The three-dimensional structure of an antibody (39-A11) that catalyzes a Diels-Alder reaction has been determined. The structure suggests that the antibody catalyzes this pericyclic reaction through a combination of packing and hydrogen-bonding interactions that control the relative geometries of the bound substrates and electronic distribution in the dienophile. A single somatic mutation, serine-91 of the light chain to valine, is largely responsible for the increase in affinity and catalytic activity of the affinity-matured antibody. Structural and functional studies of the germ-line precursor suggest that 39-A11 and related antibodies derive from a family of germ-line genes that have been selected throughout evolution for the ability of the encoded proteins to form a polyspecific combining site. Germ line-encoded antibodies of this type, which can rapidly evolve into high-affinity receptors for a broad range of structures, may help to expand the binding potential associated with the structural diversity of the primary antibody repertoire.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9506942}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9506942 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9506942}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Germline]] | | [[Category: Germline]] |
| [[Category: Immunoglobulin]] | | [[Category: Immunoglobulin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:48:13 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:06:26 2008'' |
