6c70

Cryo-EM structure of Orco

Loading... Status: waiting for Mol* initialization Structural highlights 6c70 is a 4 chain structure with sequence from Apoba. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: Or2 (APOBA) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The olfactory system must recognize and discriminate amongst an enormous variety of chemicals in the environment. To contend with such diversity, insects have evolved a family of odorant-gated ion channels comprised of a highly conserved co-receptor (Orco) and a divergent odorant receptor (OR) that confers chemical specificity. Here, we present the single-particle cryo-electron microscopy structure of an Orco homomer from the parasitic fig wasp Apocrypta bakeri at 3.5 A resolution, providing structural insight into this receptor family. Orco possesses a novel channel architecture, with four subunits symmetrically arranged around a central pore that diverges into four lateral conduits that open to the cytosol. The Orco tetramer has few inter-subunit interactions within the membrane and is bound together by a small cytoplasmic anchor domain. The minimal sequence conservation among ORs maps largely to the pore and anchor domain, shedding light on how the architecture of this receptor family accommodates its remarkable sequence diversity and facilitates the evolution of odour tuning. Cryo-EM structure of the insect olfactory receptor Orco.,Butterwick JA, Del Marmol J, Kim KH, Kahlson MA, Rogow JA, Walz T, Ruta V Nature. 2018 Aug;560(7719):447-452. doi: 10.1038/s41586-018-0420-8. Epub 2018 Aug, 15. PMID:30111839 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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