2sn3: Difference between revisions

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<StructureSection load='2sn3' size='340' side='right'caption='[[2sn3]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='2sn3' size='340' side='right'caption='[[2sn3]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2sn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1sn3 1sn3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SN3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2sn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bark_scorpion Bark scorpion]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1sn3 1sn3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SN3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2sn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sn3 OCA], [http://pdbe.org/2sn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2sn3 RCSB], [http://www.ebi.ac.uk/pdbsum/2sn3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2sn3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2sn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2sn3 OCA], [https://pdbe.org/2sn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2sn3 RCSB], [https://www.ebi.ac.uk/pdbsum/2sn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2sn3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SCX3_CENSC SCX3_CENSC]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>   
[[https://www.uniprot.org/uniprot/SCX3_CENSC SCX3_CENSC]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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