3wyl: Difference between revisions

<table><tr><td colspan='2'>[[3wyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WYL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KB:5-METHOXY-3-(1-PHENYL-1H-PYRAZOL-5-YL)-1-[3-(TRIFLUOROMETHYL)PHENYL]PYRIDAZIN-4(1H)-ONE'>3KB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wyk|3wyk]], [[3wym|3wym]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyl OCA], [http://pdbe.org/3wyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wyl RCSB], [http://www.ebi.ac.uk/pdbsum/3wyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyl ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>