4u7y: Difference between revisions

<table><tr><td colspan='2'>[[4u7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U7Y FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u7y OCA], [https://pdbe.org/4u7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u7y RCSB], [https://www.ebi.ac.uk/pdbsum/4u7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u7y ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/VPS4B_HUMAN VPS4B_HUMAN] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<ref>PMID:11563910</ref> <ref>PMID:14505570</ref> <ref>PMID:18687924</ref>  

*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]

[[Category: Homo sapiens]]

[[Category: Guo EZ]]

[[Category: Xu Z]]