4yd8: Difference between revisions

<table><tr><td colspan='2'>[[4yd8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YD8 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yd8 OCA], [https://pdbe.org/4yd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yd8 RCSB], [https://www.ebi.ac.uk/pdbsum/4yd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yd8 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PTHB1_HUMAN PTHB1_HUMAN] Bardet-Biedl syndrome. A chromosomal aberration involving PTHB1 has been found in Wilms tumor. Translocation t(1;7)(q42;p15) with OBSCN.  The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/PTHB1_HUMAN PTHB1_HUMAN] The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.<ref>PMID:17574030</ref> <ref>PMID:22072986</ref>  

[[Category: Homo sapiens]]

[[Category: Knockenhauer KE]]

[[Category: Schwartz TU]]