5k8k: Difference between revisions

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<StructureSection load='5k8k' size='340' side='right'caption='[[5k8k]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='5k8k' size='340' side='right'caption='[[5k8k]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5k8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haein Haein]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K8K FirstGlance]. <br>
<table><tr><td colspan='2'>[[5k8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K8K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxH, HI_0735 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k8k OCA], [https://pdbe.org/5k8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k8k RCSB], [https://www.ebi.ac.uk/pdbsum/5k8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k8k ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-2,3-diacylglucosamine_diphosphatase UDP-2,3-diacylglucosamine diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.54 3.6.1.54] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k8k OCA], [http://pdbe.org/5k8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k8k RCSB], [http://www.ebi.ac.uk/pdbsum/5k8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k8k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LPXH_HAEIN LPXH_HAEIN]] Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP.  
[https://www.uniprot.org/uniprot/LPXH_HAEIN LPXH_HAEIN] Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Haein]]
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: UDP-2,3-diacylglucosamine diphosphatase]]
[[Category: Cho J]]
[[Category: Cho, J]]
[[Category: Lee C-J]]
[[Category: Lee, C J]]
[[Category: Zhou P]]
[[Category: Zhou, P]]
[[Category: Antibiotic]]
[[Category: Calcineurin-like phosphoesterase]]
[[Category: Hydrolase]]
[[Category: Lipid some]]
[[Category: Lipid x]]
[[Category: Lipopolysaccharide]]
[[Category: Lp]]
[[Category: Lpxh]]
[[Category: Udp-diacylglucosamine]]

Latest revision as of 10:43, 27 September 2023

Structure of the Haemophilus influenzae LpxH-lipid X complex

5k8k, resolution 2.55Å

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