1a76: Difference between revisions

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[[Image:1a76.jpg|left|200px]]
{{Seed}}
[[Image:1a76.png|left|200px]]


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{{STRUCTURE_1a76|  PDB=1a76  |  SCENE=  }}  
{{STRUCTURE_1a76|  PDB=1a76  |  SCENE=  }}  


'''FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII'''
===FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII===




==Overview==
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Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii, determined at 2.0 A resolution, reveals an active site with two metal ions residing on top of a deep cleft where several conserved acidic residues are clustered. Near the active site, a long flexible loop comprised of many basic and aromatic residues forms a hole large enough to accommodate the DNA substrate. Deletion mutations in this loop significantly decreased the nuclease activity and specificity of FEN-1, suggesting that the loop is critical for recognition and cleavage of the junction between single and double-stranded regions of flap DNA.
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{{ABSTRACT_PUBMED_9699635}}


==About this Structure==
==About this Structure==
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[[Category: Rad27]]
[[Category: Rad27]]
[[Category: Rth]]
[[Category: Rth]]
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