1a7a: Difference between revisions

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[[Image:1a7a.gif|left|200px]]
{{Seed}}
[[Image:1a7a.png|left|200px]]


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{{STRUCTURE_1a7a|  PDB=1a7a  |  SCENE=  }}  
{{STRUCTURE_1a7a|  PDB=1a7a  |  SCENE=  }}  


'''STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH'''
===STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH===




==Overview==
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S-Adenosylhomocysteine (AdoHcy) hydrolase regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolyzing the potent feedback inhibitor AdoHcy to homocysteine and adenosine. The crystallographic structure determination of a selenomethionyl-incorporated AdoHcy hydrolase inhibitor complex was accomplished using single wavelength anomalous diffraction data and the direct methods program, Snb v2.0, which produced the positions of all 30 crystallographically distinct selenium atoms. The mode of enzyme-cofactor binding is unique, requiring interactions from two protein monomers. An unusual dual role for a catalytic water molecule in the active site is revealed in the complex with the adenosine analog 2'-hydroxy, 3'-ketocyclopent-4'-enyladenine.
The line below this paragraph, {{ABSTRACT_PUBMED_9586999}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9586999 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9586999}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Nad binding protein]]
[[Category: Nad binding protein]]
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