4oxs: Difference between revisions

Revision as of 12:31, 1 February 2023

Structure of NavMS in complex with channel blocking compound

Structural highlights

4oxs is a 4 chain structure with sequence from Magnetococcus marinus MC-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	2CV, BR, NA
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0L5S6_MAGMM

Publication Abstract from PubMed

Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range of neurological and cardiovascular diseases. In this study, functional electrophysiological studies show that the prokaryotic sodium channel from Magnetococcus marinus (NavMs) binds and is inhibited by eukaryotic sodium channel blockers in a manner similar to the human Nav1.1 channel, despite millions of years of divergent evolution between the two types of channels. Crystal complexes of the NavMs pore with several brominated blocker compounds depict a common antagonist binding site in the cavity, adjacent to lipid-facing fenestrations proposed to be the portals for drug entry. In silico docking studies indicate the full extent of the blocker binding site, and electrophysiology studies of NavMs channels with mutations at adjacent residues validate the location. These results suggest that the NavMs channel can be a valuable tool for screening and rational design of human drugs.

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863 doi:https://dx.doi.org/10.1073/pnas.1406855111

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OCA

[1] Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA. Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863 doi:https://dx.doi.org/10.1073/pnas.1406855111

[1]

@@ Line 3: / Line 3: @@
 <StructureSection load='4oxs' size='340' side='right'caption='[[4oxs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4oxs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OXS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4oxs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OXS FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bha|4bha]], [[4cbc|4cbc]], [[4cal|4cal]], [[4ox1|4ox1]], [[4ox4|4ox4]], [[4oxg|4oxg]], [[4oxh|4oxh]], [[4oxt|4oxt]], [[4oxu|4oxu]], [[4oy0|4oy0]], [[4oy1|4oy1]], [[4oxz|4oxz]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oxs OCA], [https://pdbe.org/4oxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oxs RCSB], [https://www.ebi.ac.uk/pdbsum/4oxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oxs ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mmc1_0798 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=156889 MAGMM])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oxs OCA], [http://pdbe.org/4oxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oxs RCSB], [http://www.ebi.ac.uk/pdbsum/4oxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oxs ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0L5S6_MAGMM A0L5S6_MAGMM]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Magmm]]
+[[Category: Magnetococcus marinus MC-1]]
-[[Category: Bagneris, C]]
+[[Category: Bagneris C]]
-[[Category: Naylor, C E]]
+[[Category: Naylor CE]]
-[[Category: Wallace, B A]]
+[[Category: Wallace BA]]
-[[Category: Channel blocking compound]]
-[[Category: Membrane protein]]
-[[Category: Pore]]
-[[Category: Sodium channel]]
-[[Category: Transport protein]]

4oxs: Difference between revisions

Revision as of 12:31, 1 February 2023

Structure of NavMS in complex with channel blocking compound

Structural highlights

Function

Publication Abstract from PubMed

References

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