6pk6: Difference between revisions

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<StructureSection load='6pk6' size='340' side='right'caption='[[6pk6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6pk6' size='340' side='right'caption='[[6pk6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6pk6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PK6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6pk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PK6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OND:4-(5-{[(2-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide'>OND</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OND:4-(5-{[(2-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide'>OND</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6pjj|6pjj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk6 OCA], [https://pdbe.org/6pk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pk6 RCSB], [https://www.ebi.ac.uk/pdbsum/6pk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk6 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk6 OCA], [http://pdbe.org/6pk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pk6 RCSB], [http://www.ebi.ac.uk/pdbsum/6pk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN]] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.  
[https://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arruda P]]
[[Category: Arruda, P]]
[[Category: Azevedo H]]
[[Category: Azevedo, H]]
[[Category: Counago RM]]
[[Category: Counago, R M]]
[[Category: Elkins JM]]
[[Category: Elkins, J M]]
[[Category: Fala AM]]
[[Category: Fala, A M]]
[[Category: Godoi PHC]]
[[Category: Godoi, P H.C]]
[[Category: Guimaraes CRW]]
[[Category: Guimaraes, C R.W]]
[[Category: Mascarello A]]
[[Category: Mascarello, A]]
[[Category: Ramos PZ]]
[[Category: Ramos, P Z]]
[[Category: Santiago AS]]
[[Category: Structural genomic]]
[[Category: Segretti N]]
[[Category: Santiago, A S]]
[[Category: Sriranganadane D]]
[[Category: Segretti, N]]
[[Category: Sriranganadane, D]]
[[Category: Serine/threonine-protein kinase prp4 homolog]]
[[Category: Sgc]]
[[Category: Splicing kinase prpf4b]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:31, 11 October 2023

Human PRPF4B bound to benzothiophene inhibitor 329

6pk6, resolution 2.10Å

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