Sandbox Reserved 1099: Difference between revisions

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'''Dermcidin''' is a '''Human''' [https://en.wikipedia.org/wiki/Antimicrobial_peptides_ antimicrobial peptide] of 109 amino acids presents in sweat involved in the regulation of skin flora. This molecule encoded by the ''DCD gene'' plays a role in the host defense system and more precisely in the [https://en.wikipedia.org/wiki/Innate_immune_system_ innate immune system] and thus, is able to prevent microbial growth after injuries or any skin disorders.  
'''Dermcidin''' is a '''Human''' [https://en.wikipedia.org/wiki/Antimicrobial_peptides_ antimicrobial peptide] of 109 amino acids presents in sweat involved in the regulation of skin flora. This molecule encoded by the ''DCD gene'' plays a role in the host defense system and thus, is able to prevent microbial growth after injuries or any skin disorders.  


== Expression and function ==
== Expression and function ==
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*[https://fr.wikipedia.org/wiki/Défensine_ Defensins] which are cationic peptides (α-defensins and β-defensins)  
*[https://fr.wikipedia.org/wiki/Défensine_ Defensins] which are cationic peptides (α-defensins and β-defensins)  


Dermcidin gene is expressed as precursor only in mucous cells of eccrine sweat glands within the dermis of the skin and the derived-peptide is secreted by granules in sweat. The active also named DCD-1 form contains the end C-terminal from the 62 to the 109 residue and is probably created by proteases in sweat.
Dermcidin gene is expressed as precursor only in mucous cells of eccrine sweat glands within the dermis of the skin and the derived-peptide is secreted by granules in sweat. The active also named DCD-1 form contains the end C-terminal from the 62 to the 109 residue and is probably created by proteases in sweat under specific conditions. The sweat is acidic and composed of salt concentration such as sodium, chloride, potassium and magnesium. The sweat is acidic and composed of


Then,
This form is involved in the [https://en.wikipedia.org/wiki/Innate_immune_system_ innate immune system] and protect from a variety of pathogenic microorganisms.


== Structural highlights ==
== Structural highlights ==