Sandbox Reserved 1095: Difference between revisions
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=== Primary and secondary structure === | === Primary and secondary structure === | ||
Human angiotensin receptor consists in a 376 amino acid string <ref> http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl </ref>. | Human angiotensin receptor consists in a 376 amino acid string <ref> http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl </ref>. | ||
- alpha helix | |||
- amino acids bound to the membrane | |||
=== Ligand binding pocket === | === Ligand binding pocket === | ||
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====Olmesartan, candesartan, telmisartan, and valsartan==== | ====Olmesartan, candesartan, telmisartan, and valsartan==== | ||
Olmesartan anchored to ATR1 by the residues <scene name='82/829348/Tyr35/ | Olmesartan anchored to ATR1 by the residues <scene name='82/829348/Tyr35/6'>Tyr35</scene>, <scene name='82/829348/Trp84/4'>Trp84</scene> and <scene name='82/829348/Arg167/2'>Arg167</scene>. | ||
Those amino acids seem to play an important role in the binding of the drug to AT1R, thanks to the formation of extensive networks of hydrogen bonds and salt bridges with the ligand <ref> http://www.jbc.org/content/290/49/29127 </ref>. | Those amino acids seem to play an important role in the binding of the drug to AT1R, thanks to the formation of extensive networks of hydrogen bonds and salt bridges with the ligand <ref> http://www.jbc.org/content/290/49/29127 </ref>. | ||
