Sandbox Reserved 1092: Difference between revisions
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{{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==5JI1 : Myostatin (GDF8)== | ==5JI1 : Myostatin (GDF8)== | ||
<StructureSection load=' | <StructureSection load='5JI1' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
<StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=' | |||
== Function == | == Function == | ||
== Structure Structural highlights == | == Structure/ Structural highlights == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== Disease/Research == | == Disease/Research == | ||
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If the quantity of myosin is not well regulated in the human body, it could trigger many muscle related illnesses<ref name="disease">Sharma, M., McFarlane, C., Kambadur, R., Kukreti, H., Bonala, S. and Srinivasan, S. (2015), Myostatin: Expanding horizons. IUBMB Life, 67: 589-600. [ https://doi.org/10.1002/iub.1392 DOI:10.1002/iub.1392]</ref>, especially when there is too much myostatin, as heart disease, liver disease.. | If the quantity of myosin is not well regulated in the human body, it could trigger many muscle related illnesses<ref name="disease">Sharma, M., McFarlane, C., Kambadur, R., Kukreti, H., Bonala, S. and Srinivasan, S. (2015), Myostatin: Expanding horizons. IUBMB Life, 67: 589-600. [ https://doi.org/10.1002/iub.1392 DOI:10.1002/iub.1392]</ref>, especially when there is too much myostatin, as heart disease, liver disease.. | ||
We can focus on the example of COPD (Chronic Obstructive Pulmonary Disease) which is a lunch disease. People suffering from this disease have difficulties to breathe because of an obstruction of airflow <ref name="disease"/> . Their muscles are not strong enough to help them to | We can focus on the example of COPD (Chronic Obstructive Pulmonary Disease) which is a lunch disease. People suffering from this disease have difficulties to breathe because of an obstruction of airflow <ref name="disease"/> . Their muscles are not strong enough to help them to breathe the right way and it is called pulmonary cachexia. This disease is also characterized by many muscle complications into the whole body, including a global reduction of muscle mass. It has been proven that a high rate of myostatin quantity in human body can promote this disease. | ||
Myostatin has also a role in many metabolisms as in blood glucose<ref name="disease"/>: indeed, the more myostatin you have, the more resistant to insulin you are. This could be link with Type 2 diabetes and so obesity because it is an inducer of Phosphotyrosine Interaction Domain containing 1 (PID1) protein [https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=55022] in human muscle cells. Indeed, this protein is known for its role into insulin resistance development. | Myostatin has also a role in many metabolisms as in blood glucose<ref name="disease"/>: indeed, the more myostatin you have, the more resistant to insulin you are. This could be link with Type 2 diabetes and so obesity because it is an inducer of Phosphotyrosine Interaction Domain containing 1 (PID1) protein [https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=55022] in human muscle cells. Indeed, this protein is known for its role into insulin resistance development. | ||
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In other cases, it is also possible to introduce follistatin to block myostatin because they will form a complex and so it will stop myostatin actions. | In other cases, it is also possible to introduce follistatin to block myostatin because they will form a complex and so it will stop myostatin actions. | ||
== Relevance == | |||
== References == | |||
<references/> | |||
