Sandbox Reserved 1091: Difference between revisions
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This protein is secreted by the Anaerobic bacterium '''Aeromonas Sobria''', which can cause potentially lethal septic shock. [http://www.mdsmanuals.com Septic Shock] is a clinical syndrome of potentially fatal organ dysfunction caused by a disorder in the response to infection. In septic shock, there is a critical reduction in tissue perfusion; acute multivisceral failure, including the lungs, kidneys and liver, can be observed. | This protein is secreted by the Anaerobic bacterium '''Aeromonas Sobria''', which can cause potentially lethal septic shock. [http://www.mdsmanuals.com Septic Shock] is a clinical syndrome of potentially fatal organ dysfunction caused by a disorder in the response to infection. In septic shock, there is a critical reduction in tissue perfusion; acute multivisceral failure, including the lungs, kidneys and liver, can be observed. | ||
ASP is a '''sepsis-related factor'''. It can cause several dysfunction like by inducing vascular leakage, reducing blood pressure via the activation of the kinin system or promoting human plasma coagulation through the activation of [fr.m.wikipedia.org/wiki/Prothrombine prothrombin]. Finally it can causes the formation of pus and edema through the action of anaphylatoxin C5a ([[4p3a]]). Gastroenteritis, and in extreme cases deuteropathy, are the main syndrome caused by infection with A. sobria. | ASP is a '''sepsis-related factor'''. It can cause several dysfunction like by inducing vascular leakage, reducing blood pressure via the activation of the kinin system or promoting human plasma coagulation through the activation of [https://fr.m.wikipedia.org/wiki/Prothrombine.com prothrombin]. Finally it can causes the formation of pus and edema through the action of anaphylatoxin C5a ([[4p3a]]). Gastroenteritis, and in extreme cases deuteropathy, are the main syndrome caused by infection with A. sobria. | ||
The '''maturation of ASP''' is achieved by ORF2. This protein plays the role of an external chaperone and is necessary for the construction of the stable ASP. Indeed, ASP doesn’t contain a propeptide (such as Kex2) that is involved in the proper folding of the protein. | The '''maturation of ASP''' is achieved by ORF2. This protein plays the role of an external chaperone and is necessary for the construction of the stable ASP. Indeed, ASP doesn’t contain a propeptide (such as Kex2) that is involved in the proper folding of the protein. | ||
