Sandbox Reserved 1096: Difference between revisions
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== Role in Human Health == | == Role in Human Health == | ||
==='''Citrullination of Myelin Basic Protein (MBP) and Multiple Sclerosis'''=== | ==='''Citrullination of Myelin Basic Protein (MBP) and Multiple Sclerosis'''=== | ||
Two main types of Arginine Deiminases are extensively expressed in the [https://en.wikipedia.org/wiki/Central_nervous_system Central Nervous System (CNS)]:PAD2 and PAD4<ref name="ARTMS"/>. PAD2, mainly produced by oligodendrocytes was found to be implicated in pathological citrullination of [https://en.wikipedia.org/wiki/Myelin_basic_protein Myelin Basic Protein (MBP)]. MBP along with oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP) play an essential role in [https://en.wikipedia.org/wiki/Myelin myelin sheath] stabilization by maintaining adequate compaction and adhesion between axonal cytoplasmic surfaces and negatively charged lipids of [https://en.wikipedia.org/wiki/Myelin myelin sheath]. | |||
==='''PAD2 and ER Target-gene Expression in Breast Cancer'''=== | ==='''PAD2 and ER Target-gene Expression in Breast Cancer'''=== | ||
