Sandbox Reserved 1092: Difference between revisions
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The folding of these structures gives Myostatin a slightly bent, hand-like shape, with 2 fingers formed by the strands described above. The palm of the hand is formed by the Helix alpha-3. The N- and C-terminal ends are situated very close to the palm and the 10 residues on the N-term side form the thumb of the hand. | The folding of these structures gives Myostatin a slightly bent, hand-like shape, with 2 fingers formed by the strands described above. The palm of the hand is formed by the Helix alpha-3. The N- and C-terminal ends are situated very close to the palm and the 10 residues on the N-term side form the thumb of the hand. | ||
The structural analysis of myostatin was achieved thanks to the proton nuclear magnetic resonance method. | The structural analysis of myostatin<ref name="Structure"> S. Daopin et al. Crystal structure of transforming growth-factor beta 2 : an unusual fold for the superfamily. Nature. 1992 Jul 17;257(5068):369-73 [https://www.ncbi.nlm.nih.gov/pubmed/1631557]</ref> was achieved thanks to the proton nuclear magnetic resonance method. | ||
== Main partners related to the structure == | == Main partners related to the structure == | ||
When in its homodimeric mature form, Myostatin is able to link with several other partners. First of all, Myostatin partners with two types of receptors : ALK 4 and ALK 5 (Activin receptor-Like Kinase). Moreover, the active form of the protein is able to link with the ActRIIB protein (Activin type II Receptor). The action of Myostatin actually requires the binding of it to these two types of membrane receptors. | When in its homodimeric mature form, Myostatin is able to link with several other partners. First of all, Myostatin partners with two types of receptors : '''ALK 4''' and '''ALK 5''' (Activin receptor-Like Kinase). Moreover, the active form of the protein is able to link with the '''ActRIIB''' protein (Activin type II Receptor). The action of Myostatin actually requires the binding of it to these two types of membrane receptors. | ||
Myostatin can also bind to diverse partners, ensuing different results : | Myostatin can also bind to diverse partners, ensuing different results : | ||
