Sandbox Reserved 1092: Difference between revisions
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== A way to cure == | == A way to cure == | ||
Myostatin | Myostatin comes of use in the curation of some diseases : | ||
Research has shown that if the myostatin's action is inhibited, the muscular mass increases <ref name="edumont"/><ref name="patho"/>.Myostatin and mostly its inhibition could thus be a solution to cure muscle atrophy diseases. For example OPMD <ref> PMID:31066242</ref> (oculopharyngeal muscular dystrophy) is a disease in which muscles affected show increased fibrosis and atrophy. It is a late-onset disease, affecting 1 over 80 000 people. It is characterized by dysphagia and ptosis, but also limb weakness when the disease has reached a very advanced stage. Researchers have noticed that the inhibition of the myostatin increased the muscular mass, thus helping to reduce the symptoms of OPMD. | Research has shown that if the myostatin's action is inhibited, the muscular mass increases <ref name="edumont"/><ref name="patho"/>.Myostatin and mostly its inhibition could thus be a solution to cure muscle atrophy diseases. For example OPMD <ref> PMID:31066242</ref> (oculopharyngeal muscular dystrophy) is a disease in which muscles affected show increased fibrosis and atrophy. It is a late-onset disease, affecting 1 over 80 000 people. It is characterized by dysphagia and ptosis, but also limb weakness when the disease has reached a very advanced stage. Researchers have noticed that the inhibition of the myostatin increased the muscular mass, thus helping to reduce the symptoms of OPMD. | ||
During the research trials, a monoclonal antibiotic is injected to mice during 10 weeks and the results showed that the muscle strength and the muscle fiber diameter increased. Moreover, the expression of the markers of muscle fibrosis reduced. However, myostatin does not cure the disease because no change was noticed the in intranuclear inclusion density, which is a characteristic of OPMD spread. It is for now only a solution to treat the symptom. | During the research trials, a monoclonal antibiotic is injected to mice during 10 weeks and the results showed that the muscle strength and the muscle fiber diameter increased. Moreover, the expression of the markers of muscle fibrosis reduced. However, myostatin does not cure the disease because no change was noticed the in intranuclear inclusion density, which is a characteristic of OPMD spread. It is for now only a solution to treat the symptom. | ||
