Sandbox Reserved 1092: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Morgane Mura (talk | contribs) No edit summary |
||
| Line 42: | Line 42: | ||
= Disease/Research = | = Disease/Research = | ||
Myostatin <ref name=" | Myostatin <ref name="Structure and synthesis"/> is a protein that has a part in muscle development : it is a negative regulator of the skeletal muscles. It has a very important role during the development of the organism, but also during its whole life. It is a very important protein with a highly conserved sequence from zebrafish to humans <ref name="patho">PMID:19412331</ref> and thus it has to be very well regulated. Indeed, there are many ways of regulation of the action of this protein and at many levels. | ||
Myostatin is a growth factor<ref name="patho"/> implicated into muscle development in mammals. It is involved in the transmission of messages to the nucleus which will promote the expression of a gene, leading to the production of ubiquitin. Ubiquitin is a signal of degradation, meaning that the muscle cells will be destroyed. Indeed, it reduces the muscular mass as well as the quantity of [[Myosin]] <ref>Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 [https://doi.org/10.1016/B978-0-323-34126-4.00036-0 DOI:10.1016/B978-0-323-34126-4.00036-0] </ref> which is very important for the cohesion of the muscles and for their movement. [[Myosin]] actually forms filament, and when these filaments associate with [[Actin]] and consume [[ATP]] it results in muscle movement. | Myostatin is a growth factor<ref name="patho"/> implicated into muscle development in mammals. It is involved in the transmission of messages to the nucleus which will promote the expression of a gene, leading to the production of ubiquitin. Ubiquitin is a signal of degradation, meaning that the muscle cells will be destroyed. Indeed, it reduces the muscular mass as well as the quantity of [[Myosin]] <ref>Jeffrey L. Corden,David Tollervey. Cell Biology, Chapter 36 Motor Proteins.2017 [https://doi.org/10.1016/B978-0-323-34126-4.00036-0 DOI:10.1016/B978-0-323-34126-4.00036-0] </ref> which is very important for the cohesion of the muscles and for their movement. [[Myosin]] actually forms filament, and when these filaments associate with [[Actin]] and consume [[ATP]] it results in muscle movement. | ||
| Line 53: | Line 53: | ||
== A way to cure == | == A way to cure == | ||
Myostatin comes of use in the curation of some diseases : | Myostatin comes of use in the curation of some diseases : | ||
Research has shown that if the myostatin's action is inhibited, the muscular mass increases <ref name=" | Research has shown that if the myostatin's action is inhibited, the muscular mass increases <ref name="Structure and synthesis"/><ref name="patho"/>.Myostatin and mostly its inhibition could thus be a solution to cure muscle atrophy diseases. For example OPMD <ref> PMID:31066242</ref> (Oculo-Pharyngeal Muscular Dystrophy) is a disease in which the muscles affected show increased fibrosis and atrophy. It is a late-onset disease, affecting 1 over 80 000 people. It is characterized by dysphagia and ptosis, but also limb weakness when the disease has reached a very advanced stage. Researchers have noticed that the inhibition of myostatin increases the muscular mass, thus helping to reduce the symptoms of OPMD. | ||
During the research trials, a monoclonal antibiotic was injected to mice during 10 weeks and the results showed that the muscle strength and the muscle fiber diameter increased. Moreover, the expression of the markers of muscle fibrosis reduced. However, myostatin does not cure the disease because no change was noticed the in intra-nuclear inclusion density, which is a characteristic of OPMD spread. It is for now only a solution to treat the symptom. | During the research trials, a monoclonal antibiotic was injected to mice during 10 weeks and the results showed that the muscle strength and the muscle fiber diameter increased. Moreover, the expression of the markers of muscle fibrosis reduced. However, myostatin does not cure the disease because no change was noticed the in intra-nuclear inclusion density, which is a characteristic of OPMD spread. It is for now only a solution to treat the symptom. | ||
In other cases, it is also possible to introduce follistatin <ref> PMID:19644449</ref> to block myostatin because they will form a complex which will stop the myostatin' action. | In other cases, it is also possible to introduce follistatin <ref> PMID:19644449</ref> to block myostatin because they will form a complex which will stop the myostatin' action. | ||
