Sandbox Reserved 1099: Difference between revisions
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== Expression | == Expression == | ||
Dermcidin gene is located on the | Dermcidin gene is located on the '''chromosome 12''' and expressed as '''precursor''' only in mucous cells of eccrine sweat glands within the dermis of the skin and the derived-peptide is then secreted by granules in sweat. | ||
The molecular weight of the DCD full-length sequence is 9,3 kDa including the signal peptide. In that way, many DCD forms could be proteolytically processed. But the most abundant DCD peptide presents in sweat is DCD-1L. | The molecular weight of the DCD full-length sequence is 9,3 kDa including the signal peptide. In that way, many DCD forms could be proteolytically processed. But the most abundant DCD peptide presents in sweat is DCD-1L. | ||
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== Antimicrobial activity == | == Antimicrobial activity == | ||
They may be effective because the sweat is acidic and composed of salt concentration such as sodium, chloride, potassium and magnesium. | They may be effective because the sweat is acidic and composed of salt concentration such as sodium, chloride, potassium and magnesium.This form is involved in the [https://en.wikipedia.org/wiki/Innate_immune_system_ innate immune system] and protect from a variety of pathogenic microorganisms. | ||
== Related disease == | == Related disease == | ||
