Sandbox TYRP1: Difference between revisions
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<Structure load='5M8L' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='5M8L' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
'''Human Tyrosinase related protein 1''' ([https://en.wikipedia.org/wiki/TYRP1 TYRP1]) is a Cu2+/Zn2+ metalloenzyme found in [http://en.wikipedia.org/wiki/Human Humans]. It is expressed in [https://en.wikipedia.org/wiki/Melanocyte melanocytes] where it plays an important role in pigmentation. TYRP1 is also involved in [https://en.wikipedia.org/wiki/Melanoma melanoma] and [https://en.wikipedia.org/wiki/Albinism albinism]. Therefore, it represents an interesting target for therapy. TYRP1 can also be called : Catalase B or Glycoprotein 75 (gp75). | '''Human Tyrosinase related protein 1''' ([https://en.wikipedia.org/wiki/TYRP1 TYRP1]) is a Cu2+/Zn2+ metalloenzyme found in [http://en.wikipedia.org/wiki/Human Humans]. It is expressed in [https://en.wikipedia.org/wiki/Melanocyte melanocytes] where it plays an important role in pigmentation. TYRP1 is also involved in [https://en.wikipedia.org/wiki/Melanoma melanoma] and [https://en.wikipedia.org/wiki/Albinism albinism]. Therefore, it represents an interesting target for therapy. TYRP1 can also be called : Catalase B or Glycoprotein 75 (gp75). <ref name="ghanem"/> | ||
== Synthesis and transport == | == Synthesis and transport == | ||
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==References== | ==References== | ||
<ref name="ghanem"/> Ghanem, G., and Fabrice, J. Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma. Molecular Oncology, 2011,5(2): 150–155. PMID: 21324755 | |||
<ref name="lai"/> Xuelei Lai, Harry J. Wichers, Montserrat Soler‐Lopez, Bauke W. Dijkstra. Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins. 2018 Jan 2 Epub 2017 Nov 28 PMID: 29052256 https://www.ncbi.nlm.nih.gov/pubmed/29052256 DOI: 10.1002/chem.201704410 https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201704410 | <ref name="lai"/> Xuelei Lai, Harry J. Wichers, Montserrat Soler‐Lopez, Bauke W. Dijkstra. Structure and Function of Human Tyrosinase and Tyrosinase‐Related Proteins. 2018 Jan 2 Epub 2017 Nov 28 PMID: 29052256 https://www.ncbi.nlm.nih.gov/pubmed/29052256 DOI: 10.1002/chem.201704410 https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201704410 | ||
<ref name = "decker"/> Decker. H, Tuczek.F. The Recent Crystal Structure of Human Tyrosinase Related Protein 1 (HsTYRP1) Solves an Old Problem and Poses a New One. 2017 Nov 13. Epub 2017 Oct 9 PMID: 28990327 https://www.ncbi.nlm.nih.gov/pubmed/28990327 DOI: 10.1002/anie.201708214 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201708214 | <ref name = "decker"/> Decker. H, Tuczek.F. The Recent Crystal Structure of Human Tyrosinase Related Protein 1 (HsTYRP1) Solves an Old Problem and Poses a New One. 2017 Nov 13. Epub 2017 Oct 9 PMID: 28990327 https://www.ncbi.nlm.nih.gov/pubmed/28990327 DOI: 10.1002/anie.201708214 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201708214 | ||
