Sandbox Reserved 1103: Difference between revisions
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== Function == | == Function == | ||
TRF1 also called TERF1 | TRF1 also called TERF1 is a protein part of the Shelterin [[https://en.wikipedia.org/wiki/Shelterin]] complex (called also telosome) that has a crucial role in the regulation of telomeres <ref>PMID: 31261825</ref>. TRF1 is an inhibitor of [[Telomerase]], the protein that elongate telomeres. Indeed, when TRF1 is inactivated, telomeres are getting longer with no regulation. | ||
The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerizes to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref>PMID: 18202258</ref> . TIN2 (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or TRF2. This link will regulated their activity and can also stabilize TRF1’s interaction with dna. | The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerizes to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref>PMID: 18202258</ref> . TIN2 (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or TRF2. This link will regulated their activity and can also stabilize TRF1’s interaction with dna. | ||
When TIN2 is mutated, telomeres are no longer regulated. TRF1 alone doesn’t seems to be efficient to regulate [[Telomerase]]. | When TIN2 is mutated, telomeres are no longer regulated. TRF1 alone doesn’t seems to be efficient to regulate [[Telomerase]]. | ||
