Sandbox Reserved 1106: Difference between revisions
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==== Primary Structure ==== | ==== Primary Structure ==== | ||
The Ago1 protein has the same 4 primary domains as all argonaut (N, PAZ, Mid, PIWI, describe in the page [ | The Ago1 protein has the same 4 primary domains as all argonaut (N, PAZ, Mid, PIWI, describe in the page [[Argonaut]]) and the two linker regions L1 (also called DUF1785 domain) and L2. Indeed, there is 84% of similitudes between the primary sequence of hAgo1 and hAgo2. Besides the N domain is interacting with L1, L2 and PIWI domains via residues 18-48 and 138-173. | ||
Besides, Argonaut 1 can be found in a lot of phylogenetic groups, with different structure. For example, in the plant ''Brachypodium distachyon'', where 10 argonauts proteins have been discovered, BdAGO1 lacks the N and Mid domains. This particularity explains the small size of this protein with only 624 residues. Moreover, BdAGO1 is related to Ago1 since the catalytic tetrad in the PIWI domain doesn’t work for it, enabling an endonuclease activity due to a missing of the last D/H residue | Besides, Argonaut 1 can be found in a lot of phylogenetic groups, with different structure. For example, in the plant ''Brachypodium distachyon'', where 10 argonauts proteins have been discovered, BdAGO1 lacks the N and Mid domains. This particularity explains the small size of this protein with only 624 residues. Moreover, BdAGO1 is related to Ago1 since the catalytic tetrad in the PIWI domain doesn’t work for it, enabling an endonuclease activity due to a missing of the last D/H residue | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
[1] Gunter Meister, et al. (2005, December). ''Identification of Novel Argonaute-Associated Proteins''. Current Biology, 2149-2155 | |||
[2] Bethany A Jawosky et al. (2006, September). ''Involvement of AGO1 and AGO2 in mammalian transcriptional silencing''. Nature Structural and Molecular biology, 787-792. | |||
[3] Ligang Wu, et al. (2008, September). ''Importance of translation and Nonnucleolytic Ago Proteins for On- Target RNA Interference''. Current Biology, 1327-1332. | |||
[4] Christopher R. Faehnle, et al. (2013, May). ''The making of a Slicer: Activation of Human Argonaute-1''. Cell Reports. | |||
[5] Daniel Völler, et al. (2016, August). ''Argonaute family protein expression in normal tissue and cancer entities''. Plos one. | |||
[6] Schalk C. et al. (2017, February). ''Small RNA-mediated repair of UV-induced DNA lesions by the DNA damagebinding protein 2 and Argonaute 1''. Proc. Natl Acad. Sci. (PNAS) USA 114, E2965–E2974. | |||
[7] Elad Elkayam, et al. (2017, August). ''Multivalent recruitment of human argonaute by GW182''. Molecular Cell, 646-658. | |||
[8] Lidiya Lisitskaya, et al. (2018). ''DNA Interference and beyond : Structure and Functions of Prokaryotic Argonaute Proteins''. Nature Communications. | |||
[9] Ena Secic, et al. (2019, October). Further Elucidation of the argonaute and dicer protein families in the model grass species Brachypodium distachyon. Frontiers in Plant Science. | |||
<references/> | <references/> | ||
