Sandbox Reserved 1095: Difference between revisions
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[https://en.wikipedia.org/wiki/Olmesartan Olmesartan] anchored to ATR1 by the residues <scene name='82/829348/Tyr35/6'>Tyr 35</scene>, <scene name='82/829348/Trp84/4'>Trp84</scene> and <scene name='82/829348/Arg167/3'>Arg167</scene>. | [https://en.wikipedia.org/wiki/Olmesartan Olmesartan] anchored to ATR1 by the residues <scene name='82/829348/Tyr35/6'>Tyr 35</scene>, <scene name='82/829348/Trp84/4'>Trp84</scene> and <scene name='82/829348/Arg167/3'>Arg167</scene>. | ||
Those three amino acids seem to play an important role in the binding of the drug to AT1R, thanks to the formation of extensive networks of hydrogen bonds and salt bridges with the ligand <ref name="Zhang2015"/>. | Those three amino acids seem to play an important role in the binding of the drug to AT1R, thanks to the formation of extensive networks of hydrogen bonds and salt bridges with the ligand <ref name="Zhang2015"/>. | ||
An other amino acid, the <scene name='82/829348/Lys199/1'>Lys 199</scene>, seems to be involved in the binding of the angiotensin II | |||
Many drugs used to cure diseases linked with the angiotensin receptor contain a [https://en.wikipedia.org/wiki/Tetrazole tetrazole] group. Studies showed that tetrazole plays an important role in the binding with AT1R. | Many drugs used to cure diseases linked with the angiotensin receptor contain a [https://en.wikipedia.org/wiki/Tetrazole tetrazole] group. Studies showed that tetrazole plays an important role in the binding with AT1R. | ||
=== Interaction with other GPCRs === | === Interaction with other GPCRs === | ||
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Several anti-hypertensive drugs are targeting the angiotensin receptor in order to block it. This kind of drugs are called [https://en.wikipedia.org/wiki/Angiotensin_II_receptor_blocker angiotensin receptor blockers (ARBs)]. This category include [https://en.wikipedia.org/wiki/Olmesartan olmesartan], [https://en.wikipedia.org/wiki/Candesartan candesartan], and [https://en.wikipedia.org/wiki/Losartan losartan]. One of the common characteristic they share is their biphenyl-tetrazole scaffold. | Several anti-hypertensive drugs are targeting the angiotensin receptor in order to block it. This kind of drugs are called [https://en.wikipedia.org/wiki/Angiotensin_II_receptor_blocker angiotensin receptor blockers (ARBs)]. This category include [https://en.wikipedia.org/wiki/Olmesartan olmesartan], [https://en.wikipedia.org/wiki/Candesartan candesartan], and [https://en.wikipedia.org/wiki/Losartan losartan]. One of the common characteristic they share is their biphenyl-tetrazole scaffold. | ||
[[Image:Sartan_drugs.png]] | [[Image:Sartan_drugs.png]] | ||
